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Selection: Yu:Z [2 articles] 

Publications by author Yu:Z.
 

Optimized arylomycins are a new class of Gram-negative antibiotics

  
Nature, Vol. 561, No. 7722. (12 September 2018), pp. 189-194, https://doi.org/10.1038/s41586-018-0483-6

Abstract

Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. Natural products and their derivatives have a key role in combating Gram-negative pathogens. Here we report chemical optimization of the arylomycins—a class of natural products with weak activity and limited spectrum—to obtain G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 inhibits the essential bacterial type I signal peptidase, a new ...

 

The Emergence of Social and Community Intelligence

  
Computer, Vol. 44, No. 7. (July 2011), pp. 21-28, https://doi.org/10.1109/mc.2011.65

Abstract

Social and community intelligence research aims to reveal individual and group behaviors, social interactions, and community dynamics by mining the digital traces that people leave while interacting with Web applications, static infrastructure, and mobile and wearable devices. ...

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Integrated Natural Resources Modelling and Management - Meta-information Database. http://mfkp.org/INRMM/author/Yu:Z

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