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Selection: Xu:M [2 articles] 

Publications by author Xu:M.
 

Optimized arylomycins are a new class of Gram-negative antibiotics

  
Nature, Vol. 561, No. 7722. (12 September 2018), pp. 189-194, https://doi.org/10.1038/s41586-018-0483-6

Abstract

Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. Natural products and their derivatives have a key role in combating Gram-negative pathogens. Here we report chemical optimization of the arylomycins—a class of natural products with weak activity and limited spectrum—to obtain G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 inhibits the essential bacterial type I signal peptidase, a new ...

 

The thermodynamic basis of entransy and entransy dissipation

  
Energy, Vol. 36, No. 7. (July 2011), pp. 4272-4277, https://doi.org/10.1016/j.energy.2011.04.016

Abstract

In the present work, the entransy and entransy dissipation are defined from the thermodynamic point of view. It is shown that the entransy is a state variable and can be employed to describe the second law of thermodynamics. For heat conduction, a principle of minimum entransy dissipation is established based on the second law of thermodynamics in terms of entransy dissipation, which leads to the governing equation of the steady Fourier heat conduction without heat source. Furthermore, we derive the expressions ...

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