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Selection: Roberts:TC [1 article] 

Publications by author Roberts:TC.
 

Optimized arylomycins are a new class of Gram-negative antibiotics

  
Nature, Vol. 561, No. 7722. (12 September 2018), pp. 189-194, https://doi.org/10.1038/s41586-018-0483-6

Abstract

Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. Natural products and their derivatives have a key role in combating Gram-negative pathogens. Here we report chemical optimization of the arylomycins—a class of natural products with weak activity and limited spectrum—to obtain G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 inhibits the essential bacterial type I signal peptidase, a new ...

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