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Selection: Kang:J [2 articles] 

Publications by author Kang:J.

Optimized arylomycins are a new class of Gram-negative antibiotics

Nature, Vol. 561, No. 7722. (12 September 2018), pp. 189-194,


Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. Natural products and their derivatives have a key role in combating Gram-negative pathogens. Here we report chemical optimization of the arylomycins—a class of natural products with weak activity and limited spectrum—to obtain G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria. G0775 inhibits the essential bacterial type I signal peptidase, a new ...


An evaluation of the software system dependency of a global atmospheric model

Monthly Weather Review (25 July 2013),


Abstract This study presents the dependency of the simulation results from a global atmospheric numerical model on machines with different hardware and software systems. The global model program (GMP) of the Global/Regional Integrated Model system (GRIMs) is tested on 10 different computer systems having different central processing unit (CPU) architectures or compilers. There exist differences in the results for different compilers, parallel libraries, and optimization levels, primarily due to the treatment of rounding errors by the different software systems. The system ...

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